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| IZGLED
I TUMACENJE SWISS-PROT BAZE PODATAKA |
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SWISS
-PROT baza podataka
SWALL
(SPTR):HIPP_HUMAN
ID HIPP_HUMAN STANDARD; PRT; 192 AA.
AC P32076; P70510; P41211;
DT 01-OCT-1993 (Rel. 27, Created)
DT 01-OCT-1994 (Rel. 30, Last sequence update)
DT 01-MAR-2002 (Rel. 41, Last annotation update)
DE NEURON SPECIFIC CALCIUM-BINDING PROTEIN HIPPOCALCIN (P23K)
(CALCIUM-
DE BINDING PROTEIN BDR-2).
GN HPCA OR BDR2.
OS Homo sapiens (Human),
OS Mus musculus (Mouse), and
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606, 10090, 10116;
RN [1]
RP SEQUENCE FROM N.A.
RC SPECIES=Human;
RX MEDLINE=94220148; PubMed=8166736;
RA Takamatsu K., Kobayashi M., Saitoh S., Fujishiro M., Noguchi
T.;
RT "Molecular cloning of human hippocalcin cDNA and chromosomal
mapping
RT of its gene.";
RL Biochem. Biophys. Res. Commun. 200:606-611(1994).
RN [2]
………………………………….
CC -!- FUNCTION: MAY BE INVOLVED IN THE CALCIUM-DEPENDENT
REGULATION OF
CC RHODOPSIN PHOSPHORYLATION. BINDS TWO CALCIUM IONS.
CC -!- TISSUE SPECIFICITY: NEURON-SPECIFIC IN THE HIPPOCAMPUS.
CC -!- PTM: MYRISTOYLATION OF HIPPOCALCIN FACILITATES INTERACTION
WITH
CC MEMBRANES.
CC -!- SIMILARITY: TO OTHER EF-HAND CALCIUM BINDING PROTEINS,
BELONGS TO
CC THE RECOVERIN SUBFAMILY.
CC --------------------------------------------------------------------------
CC This SWISS-PROT entry is copyright. It is produced through
a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL
outstation -
CC the European Bioinformatics Institute. There are no restrictions
on its
CC use by non-profit institutions as long as its content is
in no way
CC modified and this statement is not removed. Usage by and
for commercial
CC entities requires a license agreement
CC --------------------------------------------------------------------------
DR EMBL; D16593; BAA04019.1; -.
DR EMBL; AB015202; BAA74456.1; -.
DR EMBL; AB015201; BAA74456.1; JOINED.
DR EMBL; AB015200; BAA74455.1; -.
DR EMBL; AB015199; BAA74455.1; JOINED.
DR EMBL; BC001777; AAH01777.1; -.
…………………………………………………………………….
DR PIR; JC2186; JC2186.
DR PIR; JC1347; JC1347.
DR HSSP; P36610; 1G8I.
DR MIM; 142622; -.
DR MGD; MGI:1336200; Hpca.
DR InterPro; IPR002048; EF-hand.
DR InterPro; IPR001125; Recoverin.
DR Pfam; PF00036; efhand; 3.
DR PRINTS; PR00450; RECOVERIN.
DR ProDom; PD000012; EF-hand; 1.
DR SMART; SM00054; EFh; 3.
DR PROSITE; PS00018; EF_HAND; 3.
KW Calcium-binding; Repeat; Myristate.
FT INIT_MET 0 0
FT LIPID 1 1 MYRISTATE.
FT DOMAIN 35 46 ANCESTRAL CALCIUM SITE 1 (POTENTIAL).
FT CA_BIND 72 83 EF-HAND 2 (POTENTIAL).
FT CA_BIND 108 119 EF-HAND 3 (POTENTIAL).
FT CA_BIND 156 167 EF-HAND 4 (POTENTIAL).
FT CONFLICT 93 93 R -> P (IN REF. 1).
FT CONFLICT 189 189 A -> R (IN REF. 1).
SQ SEQUENCE 192 AA; 22296 MW; 9D1168E0AC3BADD7 CRC64;
GKQNSKLRPE MLQDLRENTE FSELELQEWY KGFLKDCPTG ILNVDEFKKI YANFFPYGDA
SKFAEHVFRT FDTNSDGTID FREFIIALSV TSRGRLEQKL MWAFSMYDLD GNGYISREEM
LEIVQAIYKM VSSVMKMPED ESTPEKRTEK IFRQMDTNND GKLSLEEFIR GAKSDPSIVR
LLQCDPSSAS QF
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| TUMACENJE |
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ID
identifikaciona oznaka (ovde: HIPP ljudski protein sastavljen
od 192 aminokiseline)
AC accesion number identifikacioni broj, ako ih ima
više prvi je najuobicajeniji (ovde P32076)
DT redovi daju informacije o danu unošenja sekvence
u bazu podataka i eventualnim kasnijim izmenama
DE uobicajeno ime proteina (ovde NEURON SPECIFIC CALCIUM-BINDING
PROTEIN HIPPOCALCIN )
Naredni redovi daju ime gena (GN), organizme kod kojih
je nadjen (OS) i klasifikaciju organizma u okviru bioloških
carstava(OC)
Redovi oznaceni sa RN RP RC RX RA RT RL daju listu
referenci ( deo referenci je radi preglednosti ovde izostavljen)
Listu referenci sledi lista komentara (CC). Ona pruža
informacije o funkciji proteina, tkivnoj specificnosti, lokaciji
u celiji isl. Ukoliko postoje podaci o eventualnoj slicnosti
sa odredjenom familijom proteina pružaju se ovde.
DR lista cross referenci sa drugim bazama podataka.
Ovde su dati linkovi prema drugim bazama podataka primarnim
ili sekundarnim (ovde InterPro, PRINTS, PROSITE i dr.)
KW lista kljucnih reci (ovde Calcium-binding; Repeat;
Myristate)
FT Feature table naznacava znacajne regione sekvence
kao što su lokalne sekundarne strukture, mesta vezivanja liganda,
posttranslacione modifikacije isl.
SQ daje potpunu aminokiselinsku sekvencu proteina
Izvor: Europian
Bioinformatics Institute
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